Raman Spectroscopy of Blood and Blood Components

Blood analysis by Raman spectroscopy.

Concentrations of multiple analytes were simultaneously measured in whole blood with clinical accuracy, without sample processing, using near-infrared Raman spectroscopy. Spectra were acquired with an instrument employing nonimaging optics, designed using Monte Carlo simulations of the influence of light-scattering-absorbing blood cells on the excitation and emission of Raman light in turbid me...

Terahertz Spectroscopy of Blood Components

The terahertz spectrum of human blood components and untreated swine whole blood between 0.2-1.4 THz (7-47 cm) were determined through the use of differential time-domain spectroscopy (D-TDS) techniques, with water being used as a reference. It was found that whilst significant differences between blood components and water were found at low frequencies (below 0.8 THz (27 cm)) for human blood p...

Quantitative Biological Raman Spectroscopy for Non - invasive Blood Analysis

Multicomponent blood analysis by near-infrared Raman spectroscopy.

We demonstrate the use of Raman spectroscopy to measure the concentration of many important constituents (analytes) in serum and whole blood samples at physiological concentration in vitro across a multipatient data set. A near-infrared (830-nm) diode laser generates Raman spectra that contain superpositions of Raman signals from different analytes. Calibrations for glucose, cholesterol, urea, ...

In Vivo Blood Glucose Quantification Using Raman Spectroscopy

We here propose a novel Raman spectroscopy method that permits the noninvasive measurement of blood glucose concentration. To reduce the effects of the strong background signals produced by surrounding tissue and to obtain the fingerprint Raman lines formed by blood analytes, a laser was focused on the blood in vessels in the skin. The Raman spectra were collected transcutaneously. Characterist...